OROXCELL

L'entreprise OROXCELL est spécialisée en recherches, études et analyses spécialisées, dont notamment :

• recherche et développement pharmaceutiques

At Oroxcell, we are actively committed to bringing top level partnership and services to biotech / pharmaceutical, cosmetic, food, veterinary and home products. ------- Contract Research Organisation/ Food / Alternative methods to animal use/ veterinary / bioavailability / REACH/ ECHA / in vitro / in vitro toxicity / Cellular Absorption / Liver / Hepatic / Hepatic Metabolism / Drug-Drug Interactions / DDI / hepatic DDIs / hepatic DILIs / liver DDIs / DiLis/ PK parameters pharmaco-kinetic/ QA / Quality assurance/ nutrition health / Skin irritation / Occular irritation / CRO / Caco 2 TC7 / ready to use plated caco-2 TC7 cells/ BCS Biowaiwer / Generics / Correlation curve / toxicology /safety assessment / efficacy / ADME / benefit risk/ alternative methods / to animal use/ safety evaluation / regulatory / GLP compliance study / studies / in-chemico / bio analyses / GLP / good laboratory practices / / preclinical studies / ingredients / complex mixtures / microbiota extract / finished products / AOP/ IATA / botanical extracts / formulations / raw materials / extracts / cosmetic / dermo-cosmetic / dermatology / nutrition / pharmaceutic / chemical / medical device / biotechnology / RHE / RHE micronucleus OECD 487 /RHE phototoxicity / RHE IL-18 / biotech / Intestinal / small intestine / Intestinal restitution/ Intestinal toxicity / cutaneous / intestinal absorption : intestinal permeability / Apparent permeability / cutaneous absorption OECD TG 428/ systemic / skin / reconstructed tissues / reconstructed epidermises / ocular / metabolism / absorption / permeation / tissue absorption / Tissue Distribution /tissue homogenates / organ homogenates / / h-CLAT OECD 442 E / in vitro ADME / DPRA LC MSMS OECD 442 C / Irritation / genotoxicity / microkentine nucleus / micronuclei / , sensitization, sensitisation / 3T3 NRU / OECD/ 3T3 OECD 432/ / OECD 439 skin irritation / OECD 431 skin corrosion / OECD 492 Eye Irritation / OECD 487 micronucleus / DPRA MSMS OECD 442 C / Direct Peptide Reactivity Assay / phototoxicity / method development / method validation / photosensitisation, photosensitization / mass spectrometry / cell culture / permeation intestinal / 3D organotypic human models / complex mixtures / bioanalysis / botanical extracts / hydrophobic materials / microbiota extracts / cytotoxicity / oils / tar / waxes / finished products / chronic exposure / sensitivity / specificity / accuracy / cornea / gingival / buccal / skin metabolism / screening methods / oral absorption / oral distribution / sub-lingual absorption / extrahepatic Metabolism / protein binding / keratinosens OECD 442D / subcutaneous toxicity / Ames OECD 471 / multiple reconstructed tissues / h-ClaT / hepatic stability / intestinal stability gastro intestinal aspirates / jejunum aspirates / duodenum aspirates / ileum aspirates / gastric aspirates / gut aspirates / fed - fasted / food effect / microbiota metabolism / anaerobic / fassif / fessif / absorption distribution metabolism excretion / victims perpetrators / Epiintestinal / Skinethic / Mattek / Episkin / Cellsystem / Straticell / RHE IL-18 / Full thickness / vaginal / buccal / oral / gingival / colonic / colon / medium chain fatty acids / derivatisation / pharmacology / absorbed fraction / resorption / keratine / keratinocytes / whole blood /plasma stability / / micro flora / CYP induction / CYP metabolism / UGT / SULT / phenotyping / dose dependant / linearity / plasma binding / RED / equilibrium dialysis / mass spectrometry / qPCR / mRNA / quantitative analysis / fluorescence / luminescence / UV